Development of Streptavidin-Based Nanocomplex for siRNA Delivery
نویسندگان
چکیده
منابع مشابه
Development of streptavidin-based nanocomplex for siRNA delivery.
In our previous study, we have identified a PCBP2 siRNA that exhibits antifibrotic activity in rat hepatic stellate cells (HSCs) by inhibition of αCP2, a protein responsible for stabilization of the collagen α1 (I) mRNA in alcoholic liver fibrosis. This study aims to develop a streptavidin-based nanocomplex that can efficiently deliver the PCBP2 siRNA to HSCs. Biotin-siRNA and biotin-cholestero...
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Despite the importance of siRNA delivery systems, understanding of their intracellular fate remains elusive. We recently developed a multi-component siRNA nanocomplex to deliver siRNA to hepatic stellate cells (HSCs). The objective of this study is to study post-internalization trafficking of this siRNA nanocomplex and its multiple components like siRNA, protamine, and streptavidin, in HSCs. Af...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2013
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp400355q